Endocrine Abstracts

Introduction: Type 2 diabetes mellitus (T2DM) is often associated with male hypogonadism. The role of testosterone replacement therapy (TRT) in T2DM has not been completely clarified. To systematically analyse the relationship between androgen levels and T2DM by reviewing and meta-analyzing available prospective and cross-sectional studies. In addition, a specific meta-analysis on the metabolic effects of TRT in available randomised clinical trials (RCTs) was also performed.</...

Introduction: Correct titration of basal insulin is one of the most important conditions allowing Type 2 Diabetes Mellitus patients to reach correct and personalised fasting plasma glucose. The persistence of the pandemic, together with the persistence of the SARS-CoV2 virus made titration process more complex, and pushed the Lombardy diabetologists to develop solutions which could be handled by the patient independently, or with the remote online assistance of diabetes team.<...

Introduction: Osteoporosis is a disease characterized by a low bone mass and the development of nontraumatic fractures, most commonly in the spine. However, bone mineral density (BMD) alone is not completely satisfactory in vertebral fracture risk assessment.Aim of the study: To identify clinical and laboratoristic factors associated with an increased risk of vertebral fractures in osteoporotic Caucasian women and to define a new clinically relevant scal...

Cushing’s disease (CD) is the most common cause of endogenous Cushing’s syndrome in children and adolescents and represents a rare cause of short stature. A 14-year-old boy came to our attention for progressive weight gain and short stature. Birth length and weight were normal; clinical history was negative for use of glucocorticoids. At examination, height was 140 cm (3th centile), weight was 37.7 kg (10th centile). Tanner stage was: G2, PH 3, testis 3 ml. Hypothyro...

Subclinical CS, mild hypercortisolism without overt clinical manifestations, is the most frequent (5–8%) hormonal abnormality detected in patients with secreting adrenal incidentalomas.Unclear clinical features and mild hypercortisolism make the diagnosis problematic, although laboratory criteria have recently been reviewed. In these cases, scintiscan is a central tool to define the adrenal functional activity.A 60-year-old ma...

Background: Overt hyperthyroidism can have a negative impact on pregnancy’s outcome, if not correctly treated. Furthermore anti thyroid treatment are burned by possible side effects.Objectives: We describe the experience of our center in the management of endogenous hyperthyroidism in pregnancy. evaluating the effects of the disease and treatments on fetal and maternal health.Methods: We observed 36 pregnancies (4 twins and 1 ...

Antipituitary antibodies (APA) are frequently present in patients with autoimmune polyendocrine syndrome (APS) but their role in predicting autoimmune hypophysitis (LYH) is still discussed.To evaluate the predictive value of APA investigated by immunofluorescence for the occurrence of pituitary autoimmune dysfunction when considering together some methodological characteristics as immunostaining pattern and antibody titers, we studied 149 APA positive an...

Introduction: Erectile dysfunction (ED) and, in particular, arteriogenic ED have been proposed as new markers of risk for incident major adverse cardiovascular events (MACE). Reduced penile blood flow is more common in obese people than in leaner ED subjects. The aim of this study is to explore the interaction of overweight/obesity and penile blood flow in the prediction of incident MACE.Methods: This is an observational prospective cohort study evaluati...

The exposure of cells to high glucose concentrations is considered a determinant of diabetic neuropathy. Conversely, members of the Insulin-like Growth Factor (IGF) system are well known neurotrophic factors. Here, we investigated the effects of constant and intermittent high glucose concentrations on IGF-I and IGF Binding Proteins (IGFBPs) in human neuroblast long-term cell cultures (FNC). We first demonstrated that FNC express the IGF-I receptor, and express and release in t...

Objectives: Erectile dysfunction (ED) is often associated with a wide array of psychiatric symptoms, although few studies systematically address their specific association with ED determinants. Aim of this study is to explore the relationship between ED and different psychopathological symptoms.Design and methods: A consecutive series of 1388 (mean age 51±13 years) male patients with ED was studied. Several hormonal and biochemical parameters were i...